HILIC-MS for Untargeted Profiling of the Free Glycation Product Diversity.

ABSTRACT: Glycation products produced by the non-enzymatic reaction between reducing carbohydrates and amino compounds have received increasing attention in both food- and health-related research. Although liquid chromatography mass spectrometry (LC-MS) methods for analyzing glycation products already exist, only a few common advanced glycation end products (AGEs) are usually covered by quantitative methods. Untargeted methods for comprehensively analyzing glycation products are still lacking. The aim of this study was to establish a method for simultaneously characterizing a wide range of free glycation products using the untargeted metabolomics approach. In this study, Maillard model systems consisting of a multitude of heterogeneous free glycation products were chosen for systematic method optimi

SUBMITTER: Yan Y 

PROVIDER: S-EPMC9783660 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature