Design, Synthesis and Fungicidal Activity of N-(thiophen-2-yl) Nicotinamide Derivatives.

ABSTRACT: Based on the modification of natural products and the active substructure splicing method, a series of new N-(thiophen-2-yl) nicotinamide derivatives were designed and synthesized by splicing the nitrogen-containing heterocycle natural molecule nicotinic acid and the sulfur-containing heterocycle thiophene. The structures of the target compounds were identified through ¹H NMR, ¹³C NMR and HRMS spectra. The in vivo bioassay results of all the compounds against cucumber downy mildew (CDM, Pseudoperonospora cubensis (Berk.et Curt.) Rostov.) in a greenhouse indicated that compounds 4a (EC₅₀ = 4.69 mg/L) and 4f (EC₅₀ = 1.96 mg/L) exhibited excellent fungicidal activities which were higher than both diflumetorim (EC_50</

SUBMITTER: Wu H 

PROVIDER: S-EPMC9783666 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature