A Biocompatible Liquid Pillar[n]arene-Based Drug Reservoir for Topical Drug Delivery.

ABSTRACT: Advanced external preparations that possess a sustained-release effect and integrate few irritant elements are urgently needed to satisfy the special requirements of topical administration in the clinic. Here, a series of liquid pillar[n]arene-bearing varying-length oligoethylene oxide chains (OEPns) were designed and synthesized. Following rheological property and biocompatibility investigations, pillar[6]arene with triethylene oxide substituents (TEP6) with satisfactory cavity size were screened as optimal candidate compounds. Then, a supramolecular liquid reservoir was constructed from host-guest complexes between TEP6 and econazole nitrate (ECN), an external antimicrobial agent without additional solvents. In vitro drug-release studies revealed that complexation by TEP6 could regulate

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9783689 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature