Urinary Metabolic Profiling in Volunteers Undergoing Malaria Challenge in Gabon.

ABSTRACT: The interaction of malaria parasites with their human host is extensively studied, yet only few studies reported how P. falciparum infection affects urinary metabolite profiles and how this is associated with immunity. We present a longitudinal study of the urinary metabolic profiles of twenty healthy Africans with lifelong exposure to malaria and five malaria-naïve Europeans, who were all challenged with direct venous inoculation of live P. falciparum sporozoïtes (PfSPZ) and followed up until they developed symptoms or became thick blood smear positive (TBS). Urine samples were collected before and at 2, 5, 9 and 11 days post challenge and were analysed. Upon infection, all Europeans became TBS positive, while Africans showed either a delay in time to parasitaemia or control

SUBMITTER: Betouke Ongwe ME 

PROVIDER: S-EPMC9783708 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature