Trends in the prevalence, prenatal diagnosis, and outcomes of births with chromosomal abnormalities: a hospital-based study in Zhejiang Province, China during 2014-2020.

ABSTRACT:

Background

To investigate the prevalence and prenatal diagnosis rate of chromosomal abnormalities (CA) in Zhejiang Province, China.

Methods

We estimated the annual changes in the detected prevalence of CA and prenatal diagnosis rate among 681,590 births in Zhejiang Province, China, between 2014 and 2020. Data were derived from the provincial birth defects surveillance system, which represents 30% of annual births in Zhejiang Province. The effect of maternal age was also evaluated.

Results

The detected prevalence of sex chromosomal abnormalities (1.70-7.30 per 10,000 births, P_trend < 0.001) and microdeletion and microduplication (0.30-6.81 per 10,000 births, P_trend < 0.001) gradually increased, contributing to an upward trend in overall CA (12.09-

SUBMITTER: Chen X 

PROVIDER: S-EPMC9783762 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature