High relative amount of nodular calcification in femoral plaques is associated with milder lower extremity arterial disease.

ABSTRACT:

Background

Clinical implications of different types of vascular calcification are poorly understood. The two most abundant forms of calcification, nodular and sheet calcification, have not been quantitatively analyzed in relation to the clinical presentation of lower extremity arterial disease (LEAD).

Methods

The study analyzed 51 femoral artery plaques collected during femoral endarterectomy, characterized by the presence of > 90% stenosis. Comprehensive clinical data was obtained from patient records, including magnetic resonance angiography (MRA) images, toe pressure and ankle brachial index measurements and laboratory values. The plaques were longitudinally sectioned, stained with Hematoxylin and Eosin and digitized in a deep learning platform for quantification of the r

SUBMITTER: Azeez M 

PROVIDER: S-EPMC9783794 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature