An Overview of Macrolide Resistance in Streptococci: Prevalence, Mobile Elements and Dynamics.

ABSTRACT: Streptococcal infections are usually treated with beta-lactam antibiotics, but, in case of allergic patients or reduced antibiotic susceptibility, macrolides and fluoroquinolones are the main alternatives. This work focuses on studying macrolide resistance rates, genetic associated determinants and antibiotic consumption data in Spain, Europe and also on a global scale. Macrolide resistance (MR) determinants, such as ribosomal methylases (erm(B), erm(TR), erm(T)) or active antibiotic efflux pumps and ribosomal protectors (mef(A/E)-mrs(D)), are differently distributed worldwide and associated with different clonal lineages and mobile genetic elements. MR rates vary together depending on clonal dynamics and on antibiotic consumption applying selective press

SUBMITTER: Berbel D 

PROVIDER: S-EPMC9783990 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature