Attenuation of Pseudomonas aeruginosa Virulence by Pomegranate Peel Extract.

ABSTRACT: Pseudomonas aeruginosa is an opportunistic pathogen often responsible for biofilm-associated infections. The high adhesion of bacterial cells onto biotic/abiotic surfaces is followed by production of an extracellular polysaccharidic matrix and formation of a sessile community (the biofilm) by the release of specific quorum-sensing molecules, named autoinducers (AI). When the concentrations of AI reach a threshold level, they induce the expression of many virulence genes, including those involved in biofilm formation, motility, pyoverdine and pyocyanin release. P. aeruginosa embedded into biofilm becomes resistant to both conventional drugs and the host's immune response. Accordingly, biofilm-associated infections are a major clinical problem underlining the need for new antim

SUBMITTER: Peppoloni S 

PROVIDER: S-EPMC9784079 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature