Target Metabolites to Slow Down Progression of Amyotrophic Lateral Sclerosis in Mice.

ABSTRACT: Microbial metabolites affect the neuron system and muscle cell functions. Amyotrophic lateral sclerosis (ALS) is a multifactorial neuromuscular disease. Our previous study has demonstrated elevated intestinal inflammation and dysfunction of the microbiome in patients with ALS and an ALS mouse model (human-SOD1^G93A transgenic mice). However, the metabolites in ALS progression are unknown. Using an unbiased global metabolomic measurement and targeted measurement, we investigated the longitudinal changes of fecal metabolites in SOD1^G93A mice over the course of 13 weeks. We further compared the changes of metabolites and inflammatory response in age-matched wild-type (WT) and SOD1^G93A mice treated with the bacterial product butyrate. We found changes in carbohy

SUBMITTER: Ogbu D 

PROVIDER: S-EPMC9784240 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature