Leukocyte Telomeric G-Tail Length Shortening Is Associated with Esophageal Cancer Recurrence.

ABSTRACT: Despite significant advances in therapeutics for esophageal cancer (ESC) in the past decade, it remains the sixth most fatal malignancy, with a poor 5-year survival rate (approximately 10%). There is an urgent need to improve the timely diagnosis to aid the prediction of the therapeutic response and prognosis of patients with ESC. The telomeric G-tail plays an important role in the chromosome protection. However, aging and age-related diseases lead to its shortening. Therefore, the G-tail length has been proposed as a novel potential biomarker. In the present study, to examine the possibility of G-tail shortening in patients with ESC, we measured the leukocyte telomere length (LTL) and the G-tail length using a hybridization protection assay in 147 patients with ESC and 170 age-matched hea

SUBMITTER: Han J 

PROVIDER: S-EPMC9784295 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature