Diversity, Dynamics and Therapeutic Application of Clostridioides difficile Bacteriophages.

ABSTRACT: Clostridioides difficile causes antibiotic-induced diarrhoea and pseudomembranous colitis in humans and animals. Current conventional treatment relies solely on antibiotics, but C. difficile infection (CDI) cases remain persistently high with concomitant increased recurrence often due to the emergence of antibiotic-resistant strains. Antibiotics used in treatment also induce gut microbial imbalance; therefore, novel therapeutics with improved target specificity are being investigated. Bacteriophages (phages) kill bacteria with precision, hence are alternative therapeutics for the targeted eradication of the pathogen. Here, we review current progress in C. difficile phage research. We discuss tested strategies of isolating C. difficile phages directly, and via en

SUBMITTER: Nale JY 

PROVIDER: S-EPMC9784644 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature