Unbiased Identification of Dengue Virus Non-Structural Protein 1 Peptides for Use in Vaccine Design.

ABSTRACT: Dengue virus (DENV) is a global health problem, with over half of the world's population at risk for infection. Despite this, there is only one licensed vaccine available to prevent infection and safety concerns limit immunization to only a subset of individuals. Most dengue virus vaccine efforts attempt to evoke broadly neutralizing antibodies against structural proteins. However, eliciting antibodies to block the activity of viral proteins involved in pathogenesis could be a useful complementary approach. Studies suggest that non-structural protein 1, which participates in disruption of the endothelial barrier and is hypothesized to play a significant role in the progression to severe dengue, could be a promising target for vaccine efforts. Here, we used an unbiased approach to identify

SUBMITTER: Warner NL 

PROVIDER: S-EPMC9784660 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature