Kreon^® (Creon^®) vs. Lipancrea^®: In Vitro Comparison of Two Encapsulated Pancreatin Preparations.

ABSTRACT: Kreon^® (Creon^®) and Lipancrea^® are pancreatic enzyme supplements indicated in the treatment of exocrine pancreatic insufficiency. In order to determine their interchangeability, an in vitro comparison of their physical properties and enzymatic activity was carried out. Capsule fill weight and particle size were also determined in order to establish their physical properties. Amylase, lipase and protease activities, lipase release at different pHs and the dissolution time of pellets were assessed for enzymatic analysis. The length range of Kreon^® and Lipancrea^® pellets was 1.1-2.2 mm and 1.5-2.8 mm, respectively. Protease activity was below the label claim for Lipancrea^® and above for Kreon^® presentations. L

SUBMITTER: Hartmann S 

PROVIDER: S-EPMC9784799 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature