Effect of the Type VI Secretion System Secreted Protein Hcp on the Virulence of Aeromonas salmonicida.

ABSTRACT: Aeromonas salmonicida, a psychrophilic bacterial pathogen, is widely distributed in marine freshwater, causing serious economic losses to major salmon farming areas in the world. At present, it is still one of the most important pathogens threatening salmon farming. Hcp (haemolysin-coregulated protein) is an effector protein in the type-VI secretion system (T6SS), which is secreted by T6SS and functions as its structural component. The results of our previous genomic sequencing showed that hcp existed in the mesophilic A. salmonicida SRW-OG1 isolated from naturally infected Epinephelus coioides. To further explore the role of Hcp in A. salmonicida SRW-OG1, we constructed an hcp-RNAi strain and verified its effect on the virulence of A. salmonici

SUBMITTER: Cai H 

PROVIDER: S-EPMC9784854 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature