Drug allergy evaluation in children with suspected mild antibiotic allergy.

ABSTRACT:

Background

Adverse antibiotic reactions caused by an immunological mechanism are known as allergic reactions. The percentage of reported antibiotic allergies is likely to differ from the one validated after a drug provocation test (DPT) with the culprit antibiotic. This study aimed to compare the percentage of children who were thought to be allergic to a certain antibiotic with those who have a true allergy, as confirmed by DPTs. We also validated Skin Prick Tests (SPTs) and Intradermal Tests (IDTs) by assessing their sensitivity and specificity, in diagnosing antibiotic allergies using DPT as the gold standard. Furthermore, we investigated epidemiological risk factors such as personal and family history of atopic disease and eosinophilia.

Methods

Children with a history of

SUBMITTER: Kitsos N 

PROVIDER: S-EPMC9784922 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature