NLRP6 Induces Lung Injury and Inflammation Early in Brucella and Influenza Coinfection.

ABSTRACT: (1) Background: With the resurgence of brucellosis epidemics in China in recent years, the chances of a brucella coinfection with other common respiratory pathogens, such as the influenza virus, have increased dramatically. However, little is known about the pathogenicity or the mechanisms of brucella and influenza coinfections. (2) Methods: To clarify the interventions in the early stages of lung damage due to brucella and influenza coinfections, we evaluated the effect of the coinfection on disease progression and mortality using a coinfection model in WT mice and NLRP6^-/- mice, and we verified the function of NLRP6 in infection and proinflammation. (3) Results: The coinfection induced significant respiratory symptoms, weight loss, and a high mortality rate in WT mice. Influen

SUBMITTER: Shi B 

PROVIDER: S-EPMC9785007 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature