Genetic Polymorphism in Angiotensinogen and Its Association with Cardiometabolic Diseases.

ABSTRACT: Angiotensinogen (AGT) is one of the most significant enzymes of the renin-angiotensin-aldosterone system (RAAS) which is involved in the regulation and maintenance of blood pressure. AGT is involved in the production of angiotensin I which is then converted into angiotensin II that leads to renal homeostasis. However, various genetic polymorphisms in AGT have been discovered in recent times which have shown an association with various diseases. Genetic polymorphism increases the level of circulating AGT in blood which exaggerates the effects produced by AGT. The associated diseases occur due to various effects produced by increased AGT levels. Several cardiovascular diseases including myocardial infarction, coronary heart disease, heart failure, hypertrophy, etc. are associated with AGT po

SUBMITTER: Shahid M 

PROVIDER: S-EPMC9785123 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature