Proteasome Dysfunction Leads to Suppression of the Hypoxic Response Pathway in Arabidopsis.

ABSTRACT: Proteasome is a large proteolytic complex that consists of a 20S core particle (20SP) and 19S regulatory particle (19SP) in eukaryotes. The proteasome degrades most cellular proteins, thereby controlling many key processes, including gene expression and protein quality control. Proteasome dysfunction in plants leads to abnormal development and reduced adaptability to environmental stresses. Previous studies have shown that proteasome dysfunction upregulates the gene expression of proteasome subunits, which is known as the proteasome bounce-back response. However, the proteasome bounce-back response cannot explain the damaging effect of proteasome dysfunction on plant growth and stress adaptation. To address this question, we focused on downregulated genes caused by proteasome dysfunction.

SUBMITTER: Xia X 

PROVIDER: S-EPMC9785350 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature