Association between γ-Glutamyl Transpeptidase and SARS-CoV-2 Spike Antibody Titers among BNT162b2 Vaccine Recipients.

ABSTRACT:

Background

Increased γ-glutamyl transpeptidase (GGT) levels can deplete plasma glutathione, which in turn impairs immune regulation; however, evidence on GGT levels and post-vaccine immunogenicity is lacking.

Objective

To examine the association between GGT and SARS-CoV-2 spike IgG antibodies.

Methods

Participants were 1479 medical staff (aged 21 to 75 years) who received a SARS-CoV-2 antibody test after their second vaccine and whose GGT levels were measured before the vaccine rollout. Elevated and highly elevated GGT levels were defined as 51-80 and ≥81 U/L, respectively. Multivariable linear regression was used to calculate the means of SARS-CoV-2 spike IgG.

Results

In a basic model, both elevated and highly elevated GGT levels were associated with significa

SUBMITTER: Islam Z 

PROVIDER: S-EPMC9785427 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature