Nisoldipine Inhibits Influenza A Virus Infection by Interfering with Virus Internalization Process.

ABSTRACT: Influenza virus infections and the continuing spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are global public health concerns. As there are limited therapeutic options available in clinical practice, the rapid development of safe, effective and globally available antiviral drugs is crucial. Drug repurposing is a therapeutic strategy used in treatments for newly emerging and re-emerging infectious diseases. It has recently been shown that the voltage-dependent Ca²⁺ channel Cav1.2 is critical for influenza A virus entry, providing a potential target for antiviral strategies. Nisoldipine, a selective Ca²⁺ channel inhibitor, is commonly used in the treatment of hypertension. Here, we assessed the antiviral potential of nisoldipine against the infl

SUBMITTER: Huang Y 

PROVIDER: S-EPMC9785492 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature