Immunopathology of Renal Tissue in Fatal Cases of Dengue in Children.

ABSTRACT: Dengue virus (DENV) infection represents a worldwide public health concern and can cause damage to multiple organs, including the kidney. In this work, we investigated the histopathological changes caused by dengue virus infection along with the detection of inflammatory mediators, cytokines, and cell expression patterns in the renal tissue of three fatal cases in children. Hematoxylin and Eosin staining was performed to analyze these histopathological changes. Immunohistochemistry allowed for the detection of immunological inflammatory markers in renal tissues that were quantified and further analyzed. Vascular congestion, edema and glomerular infiltrate were observed in the three cases, in addition to the thickening of the matrix area around the glomerular capillaries and mononuclear inf

SUBMITTER: de Lima Siqueira Oliveira L 

PROVIDER: S-EPMC9785549 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature