Molecular and anatomical roadmap of stroke pathology in immunodeficient mice.

ABSTRACT:

Background

Stroke remains a leading cause of disability and death worldwide. It has become apparent that inflammation and immune mediators have a pre-dominant role in initial tissue damage and long-term recovery. Still, different immunosuppressed mouse models are necessary in stroke research e.g., to evaluate therapies using human cell grafts. Despite mounting evidence delineating the importance of inflammation in the stroke pathology, it is poorly described to what extent immune deficiency influences overall stroke outcome.

Methods

Here, we assessed the stroke pathology of popular genetic immunodeficient mouse models, i.e., NOD scid gamma (NSG) and recombination activating gene 2 (Rag2^-/-) mice as well as pharmacologically immunosuppressed mice and compared them

SUBMITTER: Weber RZ 

PROVIDER: S-EPMC9785704 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature