Exploring the Potential of High-Molar-Activity Samarium-153 for Targeted Radionuclide Therapy with [¹⁵³Sm]Sm-DOTA-TATE.

ABSTRACT: Samarium-153 is a promising theranostic radionuclide, but low molar activities (A_m) resulting from its current production route render it unsuitable for targeted radionuclide therapy (TRNT). Recent efforts combining neutron activation of ¹⁵²Sm in the SCK CEN BR2 reactor with mass separation at CERN/MEDICIS yielded high-A_m ¹⁵³Sm. In this proof-of-concept study, we further evaluated the potential of high-A_m ¹⁵³Sm for TRNT by radiolabeling to DOTA-TATE, a well-established carrier molecule binding the somatostatin receptor 2 (SSTR₂) that is highly expressed in gastroenteropancreatic neuroendocrine tumors. DOTA-TATE was labeled with ¹⁵³Sm and remained stable up to 7 days in relevant media.

SUBMITTER: Vermeulen K 

PROVIDER: S-EPMC9785812 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature