Modeling the Additive Effects of Nanoparticles and Polymers on Hydrogel Mechanical Properties Using Multifactor Analysis.

ABSTRACT: Interpenetrating networks (IPN)s have been conceived as a biomimetic tool to tune hydrogel mechanical properties to the desired target formulations. In this study, the rheological behavior of acrylamide (AAm) [2.5-10%] hydrogels crosslinked with N,N'-methylenebis(acrylamide) (Bis) [0.0625-0.25%] was characterized in terms of the saturation modulus affected by the interaction of silica nanoparticle (SiNP) nanofillers [0-5%] and dextran [0-2%] at a frequency of 1 Hz and strain rate of 1% after a gelation period of 90 min. For single-network hydrogels, a prominent transition was observed at 0.125% Bis for 2.5% AAm and 0.25% Bis for 5% AAm across the SiNP concentrations and was validated by retrospective 3-level factorial design models, as characterized by deviation from linearity in the satur

SUBMITTER: Barrett-Catton E 

PROVIDER: S-EPMC9785977 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature