[PRION⁺] States Are Associated with Specific Histone H3 Post-Translational Modification Changes.

ABSTRACT: Prions are proteins able to take on alternative conformations and propagate them in a self-templating process. In Saccharomyces cerevisiae, prions enable heritable responses to environmental conditions through bet-hedging mechanisms. Hence, [PRION⁺] states may serve as an atypical form of epigenetic control, producing heritable phenotypic change via protein folding. However, the connections between prion states and the epigenome remain unknown. Do [PRION⁺] states link to canonical epigenetic channels, such as histone post-translational modifications? Here, we map out the histone H3 modification landscape in the context of the [SWI⁺] and [PIN⁺] prion states. [SWI⁺] is propagated by Swi1, a subunit of the SWI/SNF chromatin remodel

SUBMITTER: Cobos SN 

PROVIDER: S-EPMC9786042 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature