ROS- and pH-Responsive Polydopamine Functionalized Ti₃C₂T_x MXene-Based Nanoparticles as Drug Delivery Nanocarriers with High Antibacterial Activity.

ABSTRACT: Premature drug release and poor controllability is a challenge in the practical application of tumor therapy, which may lead to poor chemotherapy efficacy and severe adverse effects. In this study, a reactive oxygen species (ROS)-cleavable nanoparticle system (MXene-TK-DOX@PDA) was designed for effective chemotherapy drug delivery and antibacterial applications. Doxorubicin (DOX) was conjugated to the surface of (3-aminopropyl)triethoxysilane (APTES)-functionalized MXene via an ROS-cleavable diacetoxyl thioketal (TK) linkage. Subsequently, the surfaces of the MXene nanosheets were coated with pH-responsive polydopamine (PDA) as a gatekeeper. PDA endowed the MXene-TK-DOX@PDA nanoparticles with superior biocompatibility and stability. The MXene-TK-DOX@PDA nanoparticles had an ultrathin plana

SUBMITTER: Zhang WJ 

PROVIDER: S-EPMC9786132 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature