Dataset Information

Normative values for esophageal functional lumen imaging probe measurements: A meta-analysis.

ABSTRACT:

Background

The functional lumen imaging probe (Endoflip™) is increasingly used for evaluation of patients with esophageal symptoms. To improve the interpretation of Endoflip™ in clinical practice, normative values with appropriate cut-off values are required.

Methods

Original clinical studies describing Endoflip™ use for measurements of esophageal motility in healthy adults were considered. Meta-analysis was performed based on published values.

Results

A total of 17 articles were included in the systematic review, 15 of which were included in the meta-analysis, representing 154 unique subjects. At 40 ml distention, the 5th-95th and 10th-90th percentiles for esophagogastric junction distensibility index (EGJ-DI) were 1.96-10.95 mm² /mmHg and 2.36-8.95 mm² /mmHg, respectively. An EGJ-DI below 2 mm² /mmHg was found in 5.4%, and below 3 mm² /mmHg in 20.1% of healthy subjects. At 50 ml distention, the 5th-95th and 10th-90th percentiles for EGJ-DI are 2.86-10.66 mm² /mmHg and 3.28-9.12 mm² /mmHg, respectively (below 2 mm² /mmHg: 0.6%, 3 mm² /mmHg: 6.3%). The 5th-95th and 10th-90th percentiles for EGJ-DI at 60 ml distention were 3.06-8.14 mm² /mmHg and 3.33-7.18 mm² /mmHg, respectively (below 2 mm² /mmHg: 0.0%, 3 mm² /mmHg: 7%). A clear cut-off for lower values was identified while a large spread in values was observed for upper limits of normal for EGJ-DI for all filling volumes.

Conclusions

Given these observations, we recommend using a cut-off of 2 mm² /mmHg for clinical practice, values below can be considered abnormal. Given that 5.4% of the healthy subjects will have an EGJ-DI below 2 mm² /mmHg at 40 ml, we recommend using the 50 and 60 ml distention volumes. The clinical use of an upper limit for normality of EGJ-DI seems questionable.

SUBMITTER: Bredenoord AJ

PROVIDER: S-EPMC9786273 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Publications

Normative values for esophageal functional lumen imaging probe measurements: A meta-analysis.

Bredenoord Albert J AJ Rancati Francesca F Lin Haiying H Schwartz Naama N Argov Mirit M

Neurogastroenterology and motility 20220605 11

<h4>Background</h4>The functional lumen imaging probe (Endoflip™) is increasingly used for evaluation of patients with esophageal symptoms. To improve the interpretation of Endoflip™ in clinical practice, normative values with appropriate cut-off values are required.<h4>Methods</h4>Original clinical studies describing Endoflip™ use for measurements of esophageal motility in healthy adults were considered. Meta-analysis was performed based on published values.<h4>Results</h4>A total of 17 article ...[more]

PMID: 35665566

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Project description:Background & aimsFunctional luminal imaging probe (FLIP) panometry provides a comprehensive evaluation of esophageal functional at the time of endoscopy, including assessment of esophageal distensibility and distension-induced esophageal contractility. However, the few and inconsistent findings from healthy individuals pose challenges to the application of FLIP to research and clinical practice. We performed FLIP panometry in asymptomatic volunteers.MethodsWe performed a prospective study of 20 asymptomatic volunteers (ages, 23-44; 14 women) who were evaluated with 16-cm FLIP positioned across the esophagogastric junction (EGJ) and distal esophagus (and in 8 subjects also repositioned at the proximal esophagus) during sedated upper endoscopy. FLIP data were analyzed with a customized program that generated FLIP panometry plots and calculated the EGJ-distensibility index (DI) and distensibility plateaus (DP) of distal and proximal esophageal body. Distension-induced esophageal contractility was also assessed.ResultsThe median EGJ-DI was 5.8 mm2/mm Hg (interquartile range [IQR], 4.9-6.7 mm2/mm Hg); all 20 subjects had an EGJ-DI greater than 2.8 mm2/mm Hg. The median DP values from all subjects tested were 20.2 mm (IQR, 19.8-20.8 mm) at the distal body, 21.1 mm (IQR, 20.3-22.9 mm) at the proximal body, and greater than 18 mm at both locations. Repetitive antegrade contractions (RACs) were observed in all 20 subjects; in 19 of 20 (95%) subjects, the RAC pattern persisted for 10 or more consecutive antegrade contractions.ConclusionsNormal parameters of FLIP panometry are EGJ-DI greater than 2.8 mm2/mm Hg, DP greater than 18 mm, and antegrade contractions that occur in a repetitive pattern (RACs)-these can be used as normal findings for esophageal distensibility and distension-induced contractility. These values can be used in comparative studies of esophageal diseases, such as achalasia and eosinophilic esophagitis, and will facilitate application of FLIP panometry to clinical practice.

Dataset Information

Normative values for esophageal functional lumen imaging probe measurements: A meta-analysis.

Background

Methods

Results

Conclusions

Publications

Normative values for esophageal functional lumen imaging probe measurements: A meta-analysis.

Similar Datasets

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