Is more always better? Dose effect in a multidomain intervention in older adults at risk of dementia.

ABSTRACT:

Background

Little is known regarding the dose-response function in multidomain interventions for dementia prevention.

Method

The Multidomain Alzheimer Preventive Trial is a 3-year randomized controlled trial comprising cognitive training, physical activity, nutrition, and omega-3 polyunsaturated fatty acids for at-risk older adults. The dose delivered (number of sessions attended) was modeled against global cognition, memory, and fluency in 749 participants. Interaction effects were assessed for age, sex, education, dementia score (CAIDE), frailty score, and apolipoprotein E (APOE) ε4 status.

Results

The dose-response models were non-linear functions indicating benefits up to about 12 to 14 training hours or 15 to 20 multidomain sessions followed by a plateau. Partici

SUBMITTER: Belleville S 

PROVIDER: S-EPMC9786573 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature