A PPARG Splice Variant in Granulosa Cells Is Associated with Polycystic Ovary Syndrome.

ABSTRACT:

Background

We explored whether there are splice variants (SVs) of peroxisome proliferator-activated receptor-gamma (PPARG) in polycystic ovary syndrome (PCOS) patients and its relationship with clinical features and KGN cell functions.

Methods

We performed a study involving 153 women with PCOS and 153 age-matched controls. One type of PPARG SV was detected by SMARTer RACE. The correlations between PPARG SV expression levels, clinical features, and KGN cell functions were analyzed. The effect of the PPARG SV on the expression of important genes in metabolism-related pathways was explored by PCR array.

Results

The expression of the PPARG SV in PCOS patients was significantly higher than that in the controls. Clinical features were more significant in the PCOS group with

SUBMITTER: Shi CY 

PROVIDER: S-EPMC9786670 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature