Comparing In Vitro Faecal Fermentation Methods as Surrogates for Phage Therapy Application.

ABSTRACT: The human microbiome and its importance in health and disease have been the subject of numerous research articles. Most microbes reside in the digestive tract, with up to 10¹² cells per gram of faecal material found in the colon. In terms of gene number, it has been estimated that the gut microbiome harbours >100 times more genes than the human genome. Several human intestinal diseases are strongly associated with disruptions in gut microbiome composition. Less studied components of the gut microbiome are the bacterial viruses called bacteriophages that may be present in numbers equal to or greater than the prokaryotes. Their potential to lyse their bacterial hosts, or to act as agents of horizontal gene transfer makes them important research targets. In this study in vitro faec

SUBMITTER: Acs N 

PROVIDER: S-EPMC9786711 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature