Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes.

ABSTRACT: Transition metal complexes have continued to constitute an appealing class of medicinal compounds since the exceptional discovery of cisplatin in the late 1960s. Pt(II)-based complexes are endowed with a broad range of biological properties, which are mainly exerted by targeting DNA. In this study, we report a significant biological investigation into and computation analyses of four Pt(II)-complexes, namely, LDP-1-4, synthesized and characterized according to previously reported procedures. Molecular-modelling studies highlighted that the top two LDP compounds (i.e., LDP-1 and LDP-4) might bind to both matched and mismatched base pair sites of the oligonucleotide 5'-(dCGGAAATTACCG)₂-3', supporting their anticancer potential. These two complexes displ

SUBMITTER: Di Pietro ML 

PROVIDER: S-EPMC9786739 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature