Characteristics of subjective cognitive decline associated with amyloid positivity.

ABSTRACT:

Introduction

The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited.

Methods

In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity.

Results

Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE ε4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with inc

SUBMITTER: Janssen O 

PROVIDER: S-EPMC9786747 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature