Carvacrol and HP-β-Cyclodextrin Complexes: Extensive Characterization and Potential Cytotoxic Effect in Human Colorectal Carcinoma Cells.

ABSTRACT: The aim of this study was to obtain solid carvacrol-cyclodextrin (CD) complexes for use in the pharmaceutical industry. To this end, the complexation of carvacrol at different pH values was studied in detail, to determine the type of CD and the reaction environment that supported the highest amount of encapsulated carvacrol. Evidence of the capability of hydroxypropyl-β-cyclodextrins (HP-β-CD) to form inclusion complexes with carvacrol (K_C = 5042 ± 176 L mol^-1) and more high complexation efficiency (2.824) was demonstrated for HP-β-CDs using two different energy sources, ultrasound (US) (K_C = 8129 ± 194 L mol^-1 24 h) and microwave irradiation (MWI) (K_C = 6909 ± 161 L mol^-1), followed by spraying the resulting solution in a s

SUBMITTER: Rodriguez-Lopez MI 

PROVIDER: S-EPMC9786748 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature