Effects of angiotensin II in the management of perioperative hypotension in kidney transplant recipients.

ABSTRACT:

Background

Due to the mechanisms of action of conventional catecholamine vasopressors, there is increased risk of renal allograft injury and adverse events in transplant recipients with fluid-refractory distributive shock during the perioperative period. As such, mechanistically alternative vasopressors like angiotensin II (ATII) may avoid these complications, but there is an absence of data supporting use in this population.

Methods

This was a single-center, single-arm, open-label, phase 4 study conducted as a 1-year pilot of 20 adult renal transplant recipients receiving ATII as their first continuous infusion vasopressor in the perioperative period. The study aim was to systematically assess the safety and hemodynamic effects of ATII. Safety was assessed based on the inci

SUBMITTER: Andrews L 

PROVIDER: S-EPMC9787019 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature