Obesogenic diet in mice compromises maternal metabolic physiology and lactation ability leading to reductions in neonatal viability.

ABSTRACT:

Aims

Diets containing high-fat and high sugar (HFHS) lead to overweight/obesity. Overweight/obesity increases the risk of infertility, and of the pregnant mother and her child for developing metabolic conditions. Overweight/obesity has been recreated in mice, but most studies focus on the effects of chronic, long-term HFHS diet exposure. Here, we exposed mice to HFHS from 3 weeks prior to pregnancy with the aim of determining impacts on fertility, and gestational and neonatal outcomes.

Methods

Time-domain NMR scanning was used to assess adiposity, glucose, and insulin tolerance tests were employed to examine metabolic physiology, and morphological and proteomic analyses conducted to assess structure and nutrient levels of maternal organs and placenta.

Results

Fertilit

SUBMITTER: Lean SC 

PROVIDER: S-EPMC9787084 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature