Allicin Alleviates Diabetes Mellitus by Inhibiting the Formation of Advanced Glycation End Products.

ABSTRACT: Advanced glycation end products (AGEs) cause damage to pancreatic β-cells and trigger oxidative stress and inflammation, which promotes the development and progression of diabetes and its complications. Therefore, it is important to inhibit the formation of AGEs as part of the treatment of diabetes. Allicin is a natural antimicrobial agent with abundant pharmacological activities, and recent studies have reported its therapeutic effects in diabetes; however, the mechanism of these therapeutic effects is still unclear. Thus, the purpose of this study was to further investigate the association between allicin treatment of diabetes and AGEs. First, we established a streptozocin (STZ)-induced diabetic rat model and treated the rats with allicin for six weeks. We measured glycolipid metabolism,

SUBMITTER: Li L 

PROVIDER: S-EPMC9787121 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature