Discovery of Novel Pimprinine and Streptochlorin Derivatives as Potential Antifungal Agents.

ABSTRACT: Pimprinine and streptochlorin are indole alkaloids derived from marine or soil microorganisms. In our previous study, they were promising lead compounds due to their potent bioactivity in preventing many phytopathogens, but further structural modifications are required to improve their antifungal activity. In this study, pimprinine and streptochlorin were used as parent structures with the combination strategy of their structural features. Three series of target compounds were designed and synthesized. Subsequent evaluation for antifungal activity against six common phytopathogenic fungi showed that some of thee compounds possessed excellent effects, and this is highlighted by compounds 4a and 5a, displaying 99.9% growth inhibition against Gibberella zeae and Altern

SUBMITTER: Liu JR 

PROVIDER: S-EPMC9787289 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature