Peptide-Based Hydrogels and Nanogels Containing Gd(III) Complexes as T₁ Relaxation Agents.

ABSTRACT: New peptide-based hydrogels incorporating Gd(III) chelates with different hydration states, molecular structures and overall negative charges ([Gd(BOPTA)]^2-), [Gd(DTPA)]^2-, and ([Gd(AAZTA)]^-) were prepared and characterized. N-terminal Fmoc- or acetyl-derivatized hexapeptides (K1, K2 and K3) containing five aliphatic amino acids (differently ordered Gly, Ala, Val, Leu and Ile) and a charged lysine at the amidated C-terminal were used for the formation of the hydrogels. Particular attention was paid to the investigation of the morphological and rheological properties of the nanoparticles, in addition to the assessment of the ability (relaxivity) of the confined complexes to accelerate the longitudinal relaxation rate of the water protons localized in the pol

SUBMITTER: Rosa E 

PROVIDER: S-EPMC9787396 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature