Factors associated with the development of second primary tumours in head and neck cancer patients.

ABSTRACT:

Introduction

The development of second primary tumours (SPTs) is one of the main causes of low survival in patients with head and neck cancer (HNC). The aim of this study was to review the evidence about factors associated with developing SPTs in patients with HNC.

Methods

An updated systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, and the search was performed in Pubmed and Scopus. Only original articles with a cohort or case-control design were included. Article quality was assessed with the Newcastle-Ottawa scale.

Results

Thirty-six and two case-control studies were included, with quality medium (n = 5) to high (n = 33). Tobacco showed a significant association with SPT development, with

SUBMITTER: Salcedo-Bellido I 

PROVIDER: S-EPMC9787413 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature