Proteomics reveals unique plasma signatures in constitutional thinness.

ABSTRACT:

Purpose

Studying the plasma proteome of control versus constitutionally thin (CT) individuals, exposed to overfeeding, may give insights into weight-gain management, providing relevant information to the clinical entity of weight-gain resistant CT, and discovering new markers for the condition.

Experimental design

Untargeted protein relative quantification of 63 CT and normal-weight individuals was obtained in blood plasma at baseline, during and after an overfeeding challenge using mass spectrometry-based proteomics.

Results

The plasma proteome of CT subjects presented limited specificity with respect to controls at baseline. Yet, CT showed lower levels of inflammatory C-reactive protein and larger levels of protective insulin-like growth factor-binding protein 2. Di

SUBMITTER: Cominetti O 

PROVIDER: S-EPMC9787820 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature