The Spatial Organization of Bacterial Transcriptional Regulatory Networks.

ABSTRACT: The transcriptional regulatory network (TRN) is the central pivot of a prokaryotic organism to receive, process and respond to internal and external environmental information. However, little is known about its spatial organization so far. In recent years, chromatin interaction data of bacteria such as Escherichia coli and Bacillus subtilis have been published, making it possible to study the spatial organization of bacterial transcriptional regulatory networks. By combining TRNs and chromatin interaction data of E. coli and B. subtilis, we explored the spatial organization characteristics of bacterial TRNs in many aspects such as regulation directions (positive and negative), central nodes (hubs, bottlenecks), hierarchical levels (top, middle, bottom) and netwo

SUBMITTER: Tian L 

PROVIDER: S-EPMC9787925 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature