Extracellular vesicles and microRNAs are altered in response to exercise, insulin sensitivity and overweight.

ABSTRACT: Extracellular vesicles induced by exercise have emerged as potential mediators of tissue crosstalk. Extracellular vesicles and their cargo miRNAs have been linked to dysglycemia and obesity in animal models, but their role in humans is unclear.

Aim

The aim of the study was to characterize the miRNA content in plasma extracellular vesicle isolates after acute and long-term exercise and to study associations between extracellular vesicle miRNAs, mRNA expression in skeletal muscle and adipose tissue, and cardiometabolic risk factors.

Methods

Sedentary men with or without dysglycemia and overweight underwent an acute bicycle test and a 12-week exercise intervention with extensive metabolic phenotyping. Gene expression in m. vastus lateralis and subcutaneous adipose tissue was mea

SUBMITTER: Doncheva AI 

PROVIDER: S-EPMC9788120 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature