Iron Status and NAFLD among European Populations: A Bidirectional Two-Sample Mendelian Randomization Study.

ABSTRACT: Background and aim: Previous observational studies have suggested a paradoxical relationship between iron status and the risk of non-alcoholic fatty liver disease (NAFLD). Observed associations in these epidemiological studies fail to show sequential temporality and suffer from problems of confounding. Therefore, we performed a bidirectional two-sample Mendelian randomization (MR) to evaluate the relationship between serum iron status and NAFLD. Methods: The inverse weighted method (IVW) meta-analysis with the fixed-effect model was the main method to estimate the relationship between iron status, including serum ferritin, iron, transferrin saturation (TSAT) and total iron-binding capacity (TIBC), and NAFLD. Weighted median, penalized weighted median, and MR Robust Adjusted P

SUBMITTER: Liu C 

PROVIDER: S-EPMC9788387 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature