LAIR1, an ITIM-Containing Receptor Involved in Immune Disorders and in Hematological Neoplasms.

ABSTRACT: Leukocyte-associated immunoglobulin (Ig)-like receptor 1 (LAIR1, CD305) belongs to the family of immune-inhibitory receptors and is widely expressed on hematopoietic mature cells, particularly on immune cells. Four different types of ligands of LAIR1 have been described, including collagens, suggesting a potential immune-regulatory function on the extracellular matrix. By modulating cytokine secretion and cellular functions, LAIR1 displays distinct patterns of expression among NK cell and T/B lymphocyte subsets during their differentiation and cellular activation and plays a major negative immunoregulatory role. Beyond its implications in physiology, the activity of LAIR1 can be inappropriately involved in various autoimmune or inflammatory disorders and has been implicated in cancer physi

SUBMITTER: Van Laethem F 

PROVIDER: S-EPMC9788452 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature