Computational Model Exploring Characteristic Pattern Regulation in Periventricular Vessels.

ABSTRACT: The developing neocortical vasculature exhibits a distinctive pattern in each layer. In murine embryos, vessels in the cortical plate (CP) are vertically oriented, whereas those in the intermediate zone (IZ) and the subventricular zone (SVZ) form a honeycomb structure. The formation of tissue-specific vessels suggests that the behavior of endothelial cells is under a specific regulatory regime in each layer, although the mechanisms involved remain unknown. In the present study, we aimed to explore the conditions required to form these vessel patterns by conducting simulations using a computational model. We developed a novel model framework describing the collective migration of endothelial cells to represent the angiogenic process and performed a simulation using two-dimensional approxima

SUBMITTER: Takigawa-Imamura H 

PROVIDER: S-EPMC9788473 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature