Predicted and actual 2-year structural and pain progression in the IMI-APPROACH knee osteoarthritis cohort.

ABSTRACT:

Objectives

The IMI-APPROACH knee osteoarthritis study used machine learning (ML) to predict structural and/or pain progression, expressed by a structural (S) and pain (P) predicted-progression score, to select patients from existing cohorts. This study evaluates the actual 2-year progression within the IMI-APPROACH, in relation to the predicted-progression scores.

Methods

Actual structural progression was measured using minimum joint space width (minJSW). Actual pain (progression) was evaluated using the Knee injury and Osteoarthritis Outcomes Score (KOOS) pain questionnaire. Progression was presented as actual change (Δ) after 2 years, and as progression over 2 years based on a per patient fitted regression line using 0, 0.5, 1 and 2-year values. Differences in predicted-pr

SUBMITTER: van Helvoort EM 

PROVIDER: S-EPMC9788822 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature