An automated feeding system for the African killifish reveals the impact of diet on lifespan and allows scalable assessment of associative learning.

ABSTRACT: The African turquoise killifish is an exciting new vertebrate model for aging studies. A significant challenge for any model organism is the control over its diet in space and time. To address this challenge, we created an automated and networked fish feeding system. Our automated feeder is designed to be open-source, easily transferable, and built from widely available components. Compared to manual feeding, our automated system is highly precise and flexible. As a proof of concept for the feeding flexibility of these automated feeders, we define a favorable regimen for growth and fertility for the African killifish and a dietary restriction regimen where both feeding time and quantity are reduced. We show that this dietary restriction regimen extends lifespan in males (but not in females

SUBMITTER: McKay A 

PROVIDER: S-EPMC9788828 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature