Photochemical diazidation of alkenes enabled by ligand-to-metal charge transfer and radical ligand transfer.

ABSTRACT: Vicinal diamines are privileged synthetic motifs in chemistry due to their prevalence and powerful applications in bioactive molecules, pharmaceuticals, and ligand design for transition metals. With organic diazides being regarded as modular precursors to vicinal diamines, enormous efforts have been devoted to developing efficient strategies to access organic diazide generated from olefins, themselves common feedstock chemicals. However, state-of-the-art methods for alkene diazidation rely on the usage of corrosive and expensive oxidants or complicated electrochemical setups, significantly limiting the substrate tolerance and practicality of these methods on large scale. Toward overcoming these limitations, here we show a photochemical diazidation of alkenes via iron-mediated ligand-to-met

SUBMITTER: Bian KJ 

PROVIDER: S-EPMC9789121 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature