Dataset Information

BMI as a predictor of high fasting blood glucose among people living with HIV in the Asia-Pacific region.

ABSTRACT:

Background

Non-Asian body mass index (BMI) classifications are commonly used as a risk factor for high fasting blood glucose (FBG). We investigated the incidence and factors associated with high FBG among people living with HIV in the Asia-Pacific region, using a World Health Organization BMI classification specific to Asian populations.

Methods

This study included people living with HIV enrolled in a longitudinal cohort study from 2003 to 2019, receiving antiretroviral therapy (ART), and without prior tuberculosis. BMI at ART initiation was categorized using Asian BMI classifications: underweight (<18.5 kg/m² ), normal (18.5-22.9 kg/m² ), overweight (23-24.9 kg/m² ), and obese (≥25 kg/m² ). High FBG was defined as a single post-ART FBG measurement ≥126 mg/dL. Factors associated with high FBG were analyzed using Cox regression models stratified by site.

Results

A total of 3939 people living with HIV (63% male) were included. In total, 50% had a BMI in the normal weight range, 23% were underweight, 13% were overweight, and 14% were obese. Median age at ART initiation was 34 years (interquartile range 29-41). Overall, 8% had a high FBG, with an incidence rate of 1.14 per 100 person-years. Factors associated with an increased hazard of high FBG included being obese (≥25 kg/m² ) compared with normal weight (hazard ratio [HR] = 1.79; 95% confidence interval [CI] 1.31-2.44; p < 0.001) and older age compared with those aged ≤30 years (31-40 years: HR = 1.47; 95% CI 1.08-2.01; 41-50 years: HR = 2.03; 95% CI 1.42-2.90; ≥51 years: HR = 3.19; 95% CI 2.17-4.69; p < 0.001).

Conclusion

People living with HIV with BMI >25 kg/m² were at increased risk of high FBG. This indicates that regular assessments should be performed in those with high BMI, irrespective of the classification used.

SUBMITTER: Khuon D

PROVIDER: S-EPMC9789206 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Publications

BMI as a predictor of high fasting blood glucose among people living with HIV in the Asia-Pacific region.

Khuon Dyna D Rupasinghe Dhanushi D Saphonn Vonthanak V Kwong Tsz-Shan TS Widhani Alvina A Chaiwarith Romanee R Ly Penh Sun PS Do Cuong Duy CD Avihingsanon Anchalee A Khusuwan Suwimon S Merati Tuti Parwati TP Van Nguyen Kinh K Kumarasamy Nagalingeswaran N Chan Yu-Jiun YJ Azwa Iskandar I Ng Oon Tek OT Kiertiburanakul Sasisopin S Tanuma Junko J Pujari Sanjay S Ditangco Rossana R Zhang Fujie F Choi Jun Yong JY Gani Yasmin Y Sangle Shashikala S Ross Jeremy J Gorbach Pamina M PM Jiamsakul Awachana A

HIV medicine 20220624 2

<h4>Background</h4>Non-Asian body mass index (BMI) classifications are commonly used as a risk factor for high fasting blood glucose (FBG). We investigated the incidence and factors associated with high FBG among people living with HIV in the Asia-Pacific region, using a World Health Organization BMI classification specific to Asian populations.<h4>Methods</h4>This study included people living with HIV enrolled in a longitudinal cohort study from 2003 to 2019, receiving antiretroviral therapy (A ...[more]

PMID: 35748404

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Dataset Information

BMI as a predictor of high fasting blood glucose among people living with HIV in the Asia-Pacific region.

Background

Methods

Results

Conclusion

Publications

BMI as a predictor of high fasting blood glucose among people living with HIV in the Asia-Pacific region.

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