Pea and lentil 7S globulin crystal structures with comparative immunoglobulin epitope mapping.

ABSTRACT: Legumes represent an affordable high protein, nutrient dense food source. However, the vast majority of legume crops contain proteins that are known allergens for susceptible individuals. These include proteins from the 7S globulin family, which comprise a vast majority of seed storage proteins. Here, the crystal structures of 7S globulins from Pisum sativum L. (pea) and Lens culinaris Medicus (lentil) are presented for the first time, including pea vicillin and convicilin, and lentil vicilin. All three structures maintain the expected 7S globulin fold, with trimeric quaternary structure and monomers comprised of β-barrel N- and C-modules. The potential impact of sequence differences on structure and packing in the different crystal space groups is noted, with potential relev

SUBMITTER: Robinson KA 

PROVIDER: S-EPMC9789324 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature